Because symptoms of NF are extremely variable, NF Central Plains strongly recommends that patients seek care from providers with NF expertise, preferably at an NF Clinic.
NF type 1 (NF1)
NF1 is the most common type of neurofibromatosis, affecting approximately 1 in 2500 births. Symptoms are usually apparent in childhood. Findings may include:
- Café-au-lait spots — coffee-colored akin spots and freckling in the underarm and groin areas
- Lisch nodules — tiny nodules on the iris of the eye, not affecting vision
- Neurofibromas and plexiform neurofibromas — tumors on the nerves
- Optic gliomas — tumors on the optic pathway
- Increased risk for certain cancers (e.g., breast cancer, malignant nerve sheath tumors)
- Learning disabilities and developmental delays — ADHD, autism and lack of social skills
- Bone development issues — scoliosis and long-bone curvature
- Hypertension and blood vessel abnormalities
NF2-related schwannomatosis (NF2-SWN)
NF2-SWN affects about 1 person in 60,000. Symptoms usually appear in teen years or early adulthood. Findings may include:
- Tumors (vestibular schwannomas) along hearing/balance nerves, typically leading to hearing loss, deafness and balance problems
- Schwannomas on nerves throughout the body and other tumors on the brain and spine
- Vision issues (cataracts or other eye anomalies)
Non-NF2 schwannomatosis (SWN)
Schwannomatosis is the least common form of NF and affects approximately 1 in 100,000 adults. Symptoms rarely appear before adulthood. Findings may include:
- Benign tumors (schwannomas) occurring most often on spinal or peripheral nerves
- Chronic nerve pain, not always related to a specific tumor
Learn More
For more in-depth information about each type of NF, visit the NF Network website.